It used to be thought that you could only diagnose Alzheimer's disease definitively after people had died. We no longer have to wait until people pass away to know for certain what the diagnosis is.
The most recent advancements in biomarkers have been in the blood. With a simple blood test, a single vial of blood can be sent in and analyzed. So this really will have a seismic change in the way that we do research and one day the way we practice clinical care.